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Flanker Justin Tipuric will captain Wales as head coach Warren Gatland makes 13 changes because of their final World Cup pool match against Uruguay.
Wing Josh Adams and centre Hadleigh Parkes will be the only players.
After recovering from appendix operation lock Adam Beard makes his first World Cup look.
Qualification has been achieved by wales and need two points to finish top of Pool D.
Wales were planning to create changes for this fixture, given the tight turnaround from Wednesdays bonus-point victory against Fiji.
The requirement to rotate the group was compounded with the number of accidents picked up with centre Jonathan Davies and Dan Biggar pushed off the field at Oita, during this game.
Gatland said George North took an knock into the need along with also the Fiji game to break contributed to Adams again starting regardless of the latter suffering a leg at that match.
Adams switches in the left right wing together using Hallam Amos producing his very first tournament appearance at 11.
Lock Bradley Davies, hooker Ryan Elias and scrum-half Aled Davies earn their first taste of action in Japan.
Injuries and spinning mean Wales have chosen Tomos Williams and scrum-halves Gareth Davies as their backs along with six forwards.
That means there is not going to be a specialist fly-half cover Rhys Patchell, that starts at 10 at Biggars absence.
Gatland has indicated the cover will probably come in Parkes, with experience of playing rugby in fly-half, or Amos, who has never played within his mature career at 10.
The replacement scrum-halves might also be requested to pay for the position.
The Wales coach says having four days involving the Fiji and Uruguay games has enforceda bit of a juggling act and array talks included asking flanker James Davies to perform at the backs.
We understood that right from the start we were planning to expose a few gamers, said Gatland.
I spoke before the World Cup [to say] we would probably go into this match with just a single 10 anyhow so we are searching for cover there also.
Its been tough with the brief turnaround, but we have a forward pack that are all fresh and fairly excited and they are looking forward to the opportunity.
The message to the players to the game against Uruguay is that the door is not shut. There are chances for players to venture out there and impress and stake a claim for the quarter-finals.
Gatland included:We talked about whether we might have set James Davies from the backs. He has plenty of sevens expertise and Justin (Tipuric) is also fairly comfortable playing in the broader channels also.
We are confident weve got cover with players and having the ability to move around if we will need to do that.
Weve had two gamers back upward in Hadleigh Parkes and Josh Adams.
Ideally wed have liked to have given Josh a break, but that has not been the case and that is the reason why weve ended up opting for a 6-2 divide with 2 nines covering the backs.
Gareth (Davies) went on the wing in the end of the Fiji game and did a very good job to us. We now have two quality nines who can cover different positions.
Wales: Halfpenny; Adams, Watkin, Parkes, Amos; Patchell, A Davies; Smith, Elias, Lewis, B Davies, Beard, Shingler, Tipuric (capt), Wainwright.
Replacements: Dee, Carre Ball James Davies, T Williams, G Davies.
Snowboarder Ellie Soutters mum speaks about discovering her voice losing her daughter and supporting others.
There was somebody out there that didnt do it and that would do it
Junk talk, haka challenges, fresh stars burning nation-uniting and bright triumphs – just how much do you remember of these legendary Rugby World Cup moments?
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