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Flanker Justin Tipuric will captain Wales as head coach Warren Gatland creates 13 adjustments due to their final World Cup pool game against Uruguay.
Wing Josh Adams and centre Hadleigh Parkes will be the only players.
After recovering from appendix operation lock Adam Beard makes his very first World Cup appearance.
Wales have achieved eligibility and need just two points to finish high in Pool D.
Wales were always planning to create changes with the fixture, given the tight turnaround out of Wednesday success against Fiji.
The requirement to rotate the squad was compounded by the number of accidents picked up during this match, together with center Jonathan Davies and fly-half Dan Biggar forced off the area at Oita.
Gatland said George North carried an ankle knock in also the need and the Fiji game to break him contributed to Adams again starting even though the latter suffering a leg at that game.
Adams switches in the wing using Hallam Amos producing his very first tournament appearance.
Hooker Ryan Elias, lock Bradley Davies and scrum-half Aled Davies make their first taste of activity from Japan.
Spinning and injuries mean Wales have chosen Gareth Davies and Tomos Williams as their backs that are sole alongside six forward.
That means there wont be a professional fly-half cover Rhys Patchell, who begins in the lack of Biggar.
Gatland has suggested the cover will come from Parkes, who has Amos, who hasnt played within his career 10, or experience of playing rugby in fly-half.
The replacement scrum-halves might also be requested to pay for the fly-half place.
The Wales coach states having four days between the Fiji and Uruguay games has imposeda tiny juggling act and array talks included asking flanker James Davies to play at the backs.
We understood that right from the start we were going to expose some players, said Gatland.
I spoke before the World Cup [to say] wed probably enter this match with just one 10 anyhow so we are searching for cover there too.
Its been hard with the brief turnaround, but weve got a backpack that are fresh and pretty excited and they are looking forward to the chance.
The message to the players to the game against Uruguay is that the door isnt closed. There are chances for gamers to venture out there and impress and stake a claim for the quarter-finals.
Gatland added:We spoke about if we could have set James Davies in the backs. He has a lot of sevens expertise and Justin (Tipuric) is also pretty comfortable playing the broader channels as well.
We are convinced weve cover with players and having the ability to move around if we will need to do that.
Weve had two gamers straight back upward in Hadleigh Parkes and Josh Adams.
Ideally we would have liked to have given Josh a break, but that has not been the case and that is the reason why weve ended up opting to get a 6-2 split with two nines covering the springs.
Gareth (Davies) moved onto the wing in the conclusion of the Fiji game and did a very good job on us. We now have two grade nines who will cover various positions.
Wales: Halfpenny; Adams, Watkin, Parkes, Amos; Patchell, A Davies; Smith, Elias, Lewis, B Davies, Beard, Shingler, Tipuric (capt), Wainwright.
Replacements: G Davies, Dee, Carre Ball, Moriarty, James Davies, T Williams.
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There was someone out there who didnt that can do it and do it
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